Thehorse.com - Full Article
by: Stacey Oke, DVM, MSc
April 19 2010, Article # 16202
Historically a rare disease, type 2 diabetes mellitus should be considered an important differential diagnosis in mature or elderly horses and ponies with weight loss and excessive drinking and urinating, advised a team of veterinarians led by Andy Durham, BSc, BVSc, CertEP, DEIM, Dipl. ECEIM, MRCVS. The team consisted of vets from England, Ireland, and the U.S.
Diabetes mellitus (DM) is a chronic elevation of blood glucose (sugar) levels. The hormone insulin, produced by the pancreas, usually maintains blood-sugar levels within very tight limits. Diabetes results due to defects in insulin secretion, action, or both.
According to Durham et al., type 2 DM (T2DM) results from a gradual onset of insulin resistance and pancreatic β cell failure (i.e., inability to produce insulin) that is only rarely diagnosed in equine practice.
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