Managing Gastric Ulcers: What the Research Says

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A look at some of the causes and management strategies, including omeprazole (Gastroguard, Ulcerguard) and esomeprazole (Nexium).

By: Shannon Pratt-Phillips, PhD. | August 21, 2024

Research into drugs, therapies and nutritional management of equine ulcers is ongoing, and new information is being published monthly. One of the biggest changes to the area of ulcer management is the distinction of Equine Squamous Gastric ulcers (ESGD) that occur in the upper, less protected region of the stomach, and Equine Glandular Gastric ulcers (EGGD), those that occur in the glandular region. By recognizing the types, and causative factors, we can be more accurate in management.

Squamous ulcers occur in the squamous area, that is above the margo plicatus, where there is little to no mucous or protection against stomach acids. Ulcers occur here generally when there is a “splashing” of acid from the lower part of the stomach, which can happen with exercise (when the abdominal muscles constrict on the stomach) or when there is less of a physical barrier between the acidic liquid and the squamous mucosa, both of which can be made worse by an exaggerated acidic environment.

Glandular ulcers occur in the areas of the lower stomach, where glands secrete acids, but where there is normally extensive mucous protection. With these ulcers, both increased acidity and reduced mucous production may contribute to ulcer development...

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