Thehorse.com - Full Article
by: A.C. Asbury, DVM
April 01 2001, Article # 2947
Can you direct me to any information regarding the effect of phenylbutazone (Bute) on the urinary tract of a gelding, specifically symptoms and prognosis for full recovery?
Phenylbutazone works by inhibiting the formation of prostaglandins, the chemical byproducts of inflammation. Prostaglandins appear to have an influence on perfusion (blood flow) into the tissues of the kidney. In certain circumstances, especially when the animal is dehydrated, phenylbutazone might induce a serious disorder called papillary necrosis by inhibiting the formation of prostaglandins. To prevent this problem, caution should be taken not to administer the drug to horses with serious dehydration due to diarrhea, overexertion, or other water depletion situations. If the need is great to reduce inflammation, the treatment should be accompanied by fluid therapy.