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Body and leg wounds treated promptly with MSCs originating in the mouth heal better than untreated wounds.
Posted by Christa Lesté-Lasserre, MA | May 20, 2022
Scientists might have just discovered a very “cheeky” solution to equine skin wounds: oral stem cells.
Mesenchymal stromal cells (MSCs) harvested from the mouth of one donor horse led to improved healing of other horses’ open body and leg wounds. The researchers’ findings suggest MSCs originating in the mouth might spur cellular changes that improve the way equine skin heals, said Olivier Lepage, DVM, PhD, of the Group for Medical and Rehabilitation Research in Sport Horses (GREMERES), part of the Centre for Equine Health at the National Veterinary School at Lyon – VetAgro Sup, in Marcy l’Etoile, France.
Skin wounds in horses—especially on the lower legs—are notoriously difficult and time-consuming to heal, Lepage said. They can create stubborn biofilms that further delay healing, and can close with tough layers of exuberant granulation tissue—also known as proud flesh—that is not only unsightly but also less stretchy than normal skin...
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